Novel association suggests multiple independent QTLs within chromosome 5q21–33 region control variation in total humans IgE levels
نویسندگان
چکیده
منابع مشابه
Association between high serum total IgE levels and D11S97 on chromosome 11q13 in Japanese subjects.
The genetic linkage of atopy to chromosome 11q13 through maternally derived alleles has been previously reported. Linkage analysis in Japanese families did not confirm the existence of a major gene for atopy at this locus under the model of autosomal dominant inheritance. However, we observed a significant association between serum total IgE levels and genetic markers at this locus both in 14 J...
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Determining the normal range of Immunoglobulin E (IgE) in any population is important for diagnosis of allergic diseases. The aim of this study was to determine normal values of IgE in children living in Tehran. Two-handed and fifty six healthy children aged one month to 14 years were selected. These children had neither parasitic infections nor atopic disease. They were divided into six groups...
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Imprinting control regions (ICRs) play a fundamental role in establishing and maintaining the non-random monoallelic expression of certain genes, via common regulatory elements such as non-coding RNAs and differentially methylated regions (DMRs) of DNA. We recently surveyed DNA methylation levels within four ICRs (H19-ICR, IGF2-DMR, KvDMR, and NESPAS-ICR) in whole-blood genomic DNA from 128 mon...
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We conducted a genome-wide scan using variance components linkage analysis to localize quantitative-trait loci (QTLs) influencing triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol, and total cholesterol (TC) levels in 3,071 subjects from 459 families with atherogenic dyslipidemia. The most significant evidence for linkage to TG levels was found...
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BACKGROUND Immunoglobulin (Ig) E is well-known to play a critical role in allergic diseases. We investigated the association between longitudinal change in total IgE level and the asthma control in patients with adult asthma. METHODS For this retrospective study, 154 patients with asthma aged 21-82 years were recruited from the allergy and pulmonary units of the Showa University Hospital. Dat...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2003
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6363968